H3K9me3 is lost at recent L1Md subfamilies in HSC. (A) Integrative genomic viewer visualization of H3K9me3 enrichment and peaks at two described loci with M-MRA or U-MRA analysis, as indicated: (left) chr2:39209585-39320316; (right) chr6:5271421–5288640 (Bulut-Karslioglu et al., 2014). (B) Plot profile representing H3K9me3 enrichment along L1Md sequences ± 1 kb flanking regions in NIR (blue) vs. IR (green) conditions. ****, P < 0.0001, Wilcoxon test.