Figure 2.
Cross-reactivity and cross-neutralization of related arthritogenic alphaviruses. (A) Dendrogram showing the phylogenetic relationship of the structural genes of related alphaviruses used for cross-neutralization testing. (B–E) Neutralization assays were performed with anti-MAYV mAbs that bound to cells infected by UNAV (B), CHIKV (C), RRV (D), or ONNV (E). Serial dilutions of the indicated mAbs were incubated with 102 FFU of the indicated alphavirus before inoculation of Vero cells as described in Fig. 1. Data are representative of two experiments performed in triplicate. Error bars represent SD within one experiment.
