Caspase-11 auto-processing and GSDMD cleavage are required to induce acute septic shock. (A and C) Kaplan-Meier survival plots for mice (n = 10 per genotype) challenged with 54 mg/kg LPS. Adjusted P values are supplied in Figs. S3 (A and B). (B) Serum IL-1β and IL-18 levels 12 h after intraperitoneal injection with 20 mg/kg LPS. Each dot represents a single animal (n = 5); error bars represent mean ± SD. Data are representative of at least two independent experiments.