WT and STING N153S mixed bone marrow chimeras. (A) Diagram depicting the approach for generation of WT littermate and STING N153S mixed bone marrow chimeras (n = 10). (B) Representative contour plots of circulating CD4⁺ (top) and CD8⁺ (bottom) donor T cells. (C) Percentage of Thy1.1⁻ WT littermate or STING N153S circulating CD4⁺ and CD8⁺ cells from mixed bone marrow chimeras. Data represent the mean of samples collected from n = 10 mice from two independent experiments. ****, P < 0.0001 by Mann–Whitney.