STING N153S mice develop spontaneous perivascular inflammation of the lung. (A) Hematoxylin and eosin (H&E) images of paraffin-embedded lung sections from 4–5-mo-old STING N153S and WT littermate control mice. Pulmonary blood vessels (v) and bronchioles (b) are indicated. Top, black arrows indicate perivascular immune cell infiltrate. Bar, 100 µm. Bottom, red arrows indicate organized thrombosis. Bar, 50 µm. (B) High-magnification H&E images of WT (left) and STING N153S (right) lung sections. Bar, 5 µm. (C) Gomori trichrome staining of WT and STING N153S lung sections. Bar, 100 µm. (D) H&E staining of WT as well as STING N153S skin from the ulcerated skin lesion on a hind limb. Bar, 50 µm. (E) H&E staining of representative STING N153S and WT littermate glomeruli. Bar, 10 µm. (F) H&E staining of WT and STING N153S spleens. Bar, 100 µm. Spleen and kidney histology is representative of n = 3 mice per genotype from three independent experiments. Skin histology is representative of n = 2 mice per genotype. Lung histology is representative of seven mice per genotype from three independent experiments.