Spontaneous disease and mortality in STING N153S mice. (A) Electropherogram of WT and STING N153S mutant alleles within exon 5. (B) Spleens from WT littermate control and STING N153S mice. (C) STING N153S mouse lungs with surrounding pleural effusions, indicated by the yellow arrows. (D) Representative skin ulcerations (yellow arrows) on the extremities and head of STING N153S mice. (E) Mortality was assessed in STING N153S male and female mice (n = 21) for 180 d. Three pregnant female mice (#) succumbed to disease. No mortality occurred in WT littermate control animals (n = 20).