Figure 2. Defective mTEC development and medulla topology in LTβRTEC mice. (A) Thymic architecture in indicated mouse strains. Bar, 500 µm. (B) Sections stained with anti-CD8 (green) to detect cortex and ERTR5 (red) to detect medulla. Bar, 500 µm. Images represent ≥4 mice. (C) Quantitation of medulla areas in sections. Data are means of three sections per mouse, n = 3 per strain. Data from three separate experiments. (D) CD80/MHCII in EpCAM1+Ly51− mTECs. (E and F) TEC quantitation in Foxn1Cre, LTβRTEC, WT, and Ltbr−/− mice. Data from four experiments, n = 12. Error bars indicate SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.
Figure 2.

Defective mTEC development and medulla topology in LTβRTEC mice. (A) Thymic architecture in indicated mouse strains. Bar, 500 µm. (B) Sections stained with anti-CD8 (green) to detect cortex and ERTR5 (red) to detect medulla. Bar, 500 µm. Images represent ≥4 mice. (C) Quantitation of medulla areas in sections. Data are means of three sections per mouse, n = 3 per strain. Data from three separate experiments. (D) CD80/MHCII in EpCAM1+Ly51− mTECs. (E and F) TEC quantitation in Foxn1Cre, LTβRTEC, WT, and Ltbr−/− mice. Data from four experiments, n = 12. Error bars indicate SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal