Figure 3.
Figure 3. Prognostic significance of FSTL1-DIAPH1 gene pair. (A) Bioluminescence imaging of systemic metastasis by A253 cells expressing luciferase reporter and control shRNA or shRNA against FSTL1 or DIAPH1 individually or in combination (n = 7). (B) Representation of the total number of metastatic foci in lung sections. Error bars denote mean ± SEM. **, P < 0.0001. (C) Representative images of lung metastatic colonies detected by staining for KRT5 on day 26 postinjection. Bars, 100 μm. (D) Scatter plot of FSTL1 and DIAPH1 expression in 262 patients, classified into four distinct segments by 2D-DDg. (E) Kaplan–Meier survival curves of individual segments. (F) Kaplan–Meier survival curves with statistical significance by log-rank test of two groups, in which patients were grouped as low risk (segments a+b+c) and high risk (segment d).

Prognostic significance of FSTL1-DIAPH1 gene pair. (A) Bioluminescence imaging of systemic metastasis by A253 cells expressing luciferase reporter and control shRNA or shRNA against FSTL1 or DIAPH1 individually or in combination (n = 7). (B) Representation of the total number of metastatic foci in lung sections. Error bars denote mean ± SEM. **, P < 0.0001. (C) Representative images of lung metastatic colonies detected by staining for KRT5 on day 26 postinjection. Bars, 100 μm. (D) Scatter plot of FSTL1 and DIAPH1 expression in 262 patients, classified into four distinct segments by 2D-DDg. (E) Kaplan–Meier survival curves of individual segments. (F) Kaplan–Meier survival curves with statistical significance by log-rank test of two groups, in which patients were grouped as low risk (segments a+b+c) and high risk (segment d).

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