Figure 6. Mafand Rorc are required for Tc17 differentiation. (A) Enumeration of Tc17 cells in WT or Tcf7−/−c-Maf+/− mice. Contour plots show the frequency of RORγt-expressing cells within live TCRβ+CD4−CD8+ T cells (upper panel). Scatter plots show the total number of TCRβ+CD4−CD8+RORγt+ Tc17 cells per spleen for each genotype (lower panel). (B) Frequency and total number of Tc17 cells in WT and Tcf7−/−Rorc(γt)+/GFP mouse strains. Contour plots show the frequency of RORγt-expressing cells within live TCRβ+CD4−CD8+ T cells (upper panel). Scatter plots show the total number of TCRβ+ CD4−CD8+RORγt+ Tc17 cells per spleen for each genotype (lower panel). (A and B) Lower panels data show individual mice (mean ± SD) pooled from three independent experiments (n = 1 or 2 mice/group/experiment). Exact P values were calculated using Student’s t test.
Figure 6.

Mafand Rorc are required for Tc17 differentiation. (A) Enumeration of Tc17 cells in WT or Tcf7−/−c-Maf+/− mice. Contour plots show the frequency of RORγt-expressing cells within live TCRβ+CD4−CD8+ T cells (upper panel). Scatter plots show the total number of TCRβ+CD4−CD8+RORγt+ Tc17 cells per spleen for each genotype (lower panel). (B) Frequency and total number of Tc17 cells in WT and Tcf7−/−Rorc(γt)+/GFP mouse strains. Contour plots show the frequency of RORγt-expressing cells within live TCRβ+CD4−CD8+ T cells (upper panel). Scatter plots show the total number of TCRβ+ CD4−CD8+RORγt+ Tc17 cells per spleen for each genotype (lower panel). (A and B) Lower panels data show individual mice (mean ± SD) pooled from three independent experiments (n = 1 or 2 mice/group/experiment). Exact P values were calculated using Student’s t test.

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