Figure 3.

Transcriptional analysis of early ILC progenitors. (A) TSCAN analysis using RNA sequencing data of ALPs, EILPs, and ILCps. (B) Heat map of gene expression quantified by RNA sequencing for all transcription factors highly expressed in at least one of the three subsets of ILC progenitors and significantly up-regulated from ALPs to EILPs or from EILPs to ILCps. (C) Heat map of gene expression quantified by RNA sequencing for structural genes highly expressed in at least one of the three subsets of ILC progenitors, significantly up-regulated from ALPs to EILPs or from EILPs to ILCps, and in the indicated biological processes (P < 0.01; fold change ≥4). (D) RNA sequencing traces of TCR-γ and TCR-β loci for ILC progenitors.

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