Mean frequencies of V–J pairing of TCR clonotypes. Frequencies include TCRα (A) and TCRβ (B) V–J pairing of unique TCR clonotypes in ABabDII mice (n = 5), ABabDR4 (n = 5) mice, and human donors (n = 3). The heat maps were arranged by frequency from greatest (red) to the least (gray; top → bottom, J segments; left → right, V segments). (Left) In-frame; (Right) Out-of-frame. TRAV1, TRBV5-1, and TRBV6-1 were excluded from the analysis for ABabDII and ABabDR4 mice; TRAV18 was excluded for all three groups.