Figure 3. Comorbid mice exhibit suppressed NK cell and CD8+ T cell activation during early influenza infection. (A and D) Mice were immunized and then inoculated as described in Fig. 1. Cellular composition of the lungs was analyzed 3 d after influenza inoculation. Shown are representative flow cytometric plots of IFN-γ production from NK cells obtained from either singly influenza or comorbid (A) and total CD8+ T cells (D). (B–F) Summary bar graphs of compiled cell percentages and numbers for total NK cells (B), IFN-γ–producing NK cells (C), compiled cell percentages and numbers for total CD8+ T cells (E), and total IFN-γ–producing CD8+ T cells (F) are from two independent experiments with at least three mice per group. Student’s t tests were conducted for statistical analysis. *, P < 0.05; **, P < 0.01; ***, P < 0.001. The mean and standard error of means are represented.
Figure 3.

Comorbid mice exhibit suppressed NK cell and CD8+ T cell activation during early influenza infection. (A and D) Mice were immunized and then inoculated as described in Fig. 1. Cellular composition of the lungs was analyzed 3 d after influenza inoculation. Shown are representative flow cytometric plots of IFN-γ production from NK cells obtained from either singly influenza or comorbid (A) and total CD8+ T cells (D). (B–F) Summary bar graphs of compiled cell percentages and numbers for total NK cells (B), IFN-γ–producing NK cells (C), compiled cell percentages and numbers for total CD8+ T cells (E), and total IFN-γ–producing CD8+ T cells (F) are from two independent experiments with at least three mice per group. Student’s t tests were conducted for statistical analysis. *, P < 0.05; **, P < 0.01; ***, P < 0.001. The mean and standard error of means are represented.

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