Tumor regressions after melanoma-reactive polyclonal CTL combined with anti-CTLA4. (A) Timeline of successive therapies. (B) Kinetics of response for three target lesions (y axis) spanning 5 yr (x axis). (C) Serial PET (leftmost image) and CT images at indicated time points. Arrows indicate the location of the right hilar (blue) and subcarinal (red) masses. (D) Photograph of the patient's depigmented eyelashes and eyebrows ∼5 mo after the start of the combined treatment.