Proposed model for neutrophil regulation of T and B cells during EG. (1) Neutropenia at the time of CFA immunization triggers induced EG by enhanced serum G-CSF levels. Lack of apoptotic neutrophils enhances IL-23 production by DCs and increases DC migration to the dLNs. (2) Increased IL-23 production by DCs induces IL-17 production by CD4⁺ T cells in the LN. IL-17 induces Cox2 expression in stromal LN cells, and the subsequent prostaglandin synthesis by Cox2 specifically recruits neutrophils to the LNs. (3) The recruited neutrophils migrate close to the B cells and with the support of G-CSF produce BAFF that directly promotes B cell activation and survival.