The NAIP/NLRC4 inflammasomes detect specific ligands. NAIP1 and NAIP2 detect the T3SS needle and rod proteins, respectively, whereas, NAIP5 and NAIP6 detect flagellin. Upon interaction with its ligand, a single NAIP recruits and activates one NLRC4, which propagates the signal to further NLRC4 molecules leading to the formation of disk-shaped oligomeric complexes composed of 1 NAIP and 9–11 NLRC4 proteins.

The NAIP/NLRC4 inflammasomes detect specific ligands. NAIP1 and NAIP2 detect the T3SS needle and rod proteins, respectively, whereas, NAIP5 and NAIP6 detect flagellin. Upon interaction with its ligand, a single NAIP recruits and activates one NLRC4, which propagates the signal to further NLRC4 molecules leading to the formation of disk-shaped oligomeric complexes composed of 1 NAIP and 9–11 NLRC4 proteins.

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