TCR-I and TCR-IV T cells reject MHC-I high Tet-TagLuc tumors, but only TCR-I reject MHC-I low 16.113p, whereas TCR-IV T cells favor escape. (A) H2-D^b and H2-K^b surface expression for Tet-TagLuc and 16.113p tumor cells stimulated with IFN-γ or left untreated and corresponding isotype controls are shown in the histograms. One representative of three experiments is shown. (B) Tet-TagLuc tumor volumes over time for Rag^−/− mice receiving TCR-I, TCR-IV, or mock-transduced P14/Rag^−/− CD8⁺ T cells. Each line represents the mean value of indicated numbers of mice receiving the same therapy. Error bars correspond to SD. Total mouse numbers from four experiments are shown in the table. (C) 16.113p tumor volumes of indicated number of Rag^−/− mice are shown for TCR-I and mock (error bars correspond to SD), and each line represents a single mouse for TCR-IV (n = 4) treatment. Total mouse numbers from five experiments are shown in the table.