Distribution of recurrent genetic lesions among RS cases. (a) In the heatmap, rows correspond to the indicated genetic lesions, and columns represent individual RS or RSII samples, color-coded based on the gene status (light gray, wild-type; dark gray, mutated or activated or disrupted). (b) Significant associations are listed with their corresponding p-value. N, mutual exclusion; P, positive association. This figure displays only the 27 RS cases characterized by WES analysis. Therefore, some of the associations and anti-correlations shown in Fig. 5 may not reach statistical significance due to the lower number of cases.