Genes recurrently mutated in RS. Percentage of RS cases (n = 27) harboring mutations in genes altered with a frequency >10% (red bars). The mutation frequency of these genes in CLL (gray bar) was obtained in a dataset of 205 CLL cases analyzed for whole-exome/whole genome sequencing (see main text). Asterisks indicate genes differentially mutated between CLL and RS based on a two-tailed Fisher’s exact test (*, P # 0.05; **, P # 0.001). Black triangles denote genes reported in the Cancer Gene Census database (http://www.sanger.ac.uk/genetics/CGP/Census/); green triangles indicate putative or proven tumor suppressor genes; and red triangles denote putative or proven oncogenes. TSG, tumor-suppressor gene; ns, not significant.