Loss of 9p is commonly acquired in RS. (a) dChip inferred CN heat map showing the magnification of deletions affecting the CDKN2A/B locus on chromosome 9 in the RS samples carrying the loss (three with paired CLL). The first three columns represent normal (diploid) samples. In the red-blue scale, white corresponds to a normal (diploid) CN log2-ratio, blue to deletion, and red to gain. (b) Percentage of RS samples harboring CDKN2A/B deletions. (c) Regions of copy-neutral LOH affecting the CDKN2A/B locus. The left-side shows the inferred probability of LOH for each case, which is displayed from blue (1) to white (0.5) to yellow (0), and the right side shows a heatmap of the median-smoothed log2 CN ratio of the locus (blue is deletion and red is gain). (d) In the heatmap, rows correspond to the indicated aberrations and columns represent individual RS samples, color-coded based on the gene status (light grey, wild-type; dark grey, altered). (e) Significant associations between genetic lesions are listed with their corresponding p-value. Prob, probability; N, mutual exclusion; P, positive association.