Patterns of genetic evolution of CLL to RS. In each case the analyzed CLL clone is represented by a purple cell, the RS clone by a blue cell, and the RSII clone by a green cell (available in cases 2–4-5). Inferred clones are represented in orange. Bold black arrows depict the clonal path between samples and the time elapsed between samples is highlighted next to the gray lines interconnecting the analyzed time points. Each therapeutic line administered to patients is represented by a red star. The number of genetic lesions acquired in the CLL-RS transition is highlighted below the RS or RSII clone, respectively. TP, time-point; yr, years; Mo, months.