Figure 9. CCL4 is responsible for the recruitment of CD4+ T cells to the skin. (A) Neutralizing CCL4 antibody inhibited migration of activated CD4+ T cells toward supernatant obtained from LPS-stimulated IMCs. Concentrations of CCL4 antibody or IgG are shown in the graph. Two experiments were performed in duplicate. (B) S100A9Tg mice were treated for 4 wk with TPA and either control IgG or neutralizing CCL4 antibody. The number of CD4+ cells in the skin is shown. (C) The amount of IL-17A in the skin of S100A9Tg mice treated with CCL4 antibody. Each group included three mice. (A–C) Mean and SD are shown. *, P < 0.05; **, P < 0.01. (D and E) The number of papillomas formed in Tg.AC (D) and S100A9Tg;Tg.AC (E) mice treated with TPA and control IgG or CCL4 antibody as indicated. Mean and SD are shown. Each group included four mice. P = 0.001 (D) and P < 0.001 (E).
Figure 9.

CCL4 is responsible for the recruitment of CD4+ T cells to the skin. (A) Neutralizing CCL4 antibody inhibited migration of activated CD4+ T cells toward supernatant obtained from LPS-stimulated IMCs. Concentrations of CCL4 antibody or IgG are shown in the graph. Two experiments were performed in duplicate. (B) S100A9Tg mice were treated for 4 wk with TPA and either control IgG or neutralizing CCL4 antibody. The number of CD4+ cells in the skin is shown. (C) The amount of IL-17A in the skin of S100A9Tg mice treated with CCL4 antibody. Each group included three mice. (A–C) Mean and SD are shown. *, P < 0.05; **, P < 0.01. (D and E) The number of papillomas formed in Tg.AC (D) and S100A9Tg;Tg.AC (E) mice treated with TPA and control IgG or CCL4 antibody as indicated. Mean and SD are shown. Each group included four mice. P = 0.001 (D) and P < 0.001 (E).

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