Figure 4. MAIT CDR3β usage is unique across individuals and pathogens. (A) Representation of unique TRBV20-1+ CDR3β sequences from each donor in response to each pathogen as indicated. Each bar represents a distinct sequence, the relative frequency of which is depicted on the y axis. TRBJ gene usage is shown on the x axis labeled for dominant sequences. (B) Distribution of CDR3β amino acid lengths from all TRBV gene–defined MAIT cells responsive to each pathogen as indicated in the key. (C) Visual representation of amino acid enrichments at each position across the CDR3β core compiled from pathogen-reactive MAIT cell TRBV+ sequences. Analysis was confined to CDR3β sequences with a length of 13 or 14 amino acids, encompassing 34 sequences for M. smegmatis, 75 for S. typhimurium, and 39 for C. albicans. Graphics were generated using Seq2Logo.
Figure 4.

MAIT CDR3β usage is unique across individuals and pathogens. (A) Representation of unique TRBV20-1+ CDR3β sequences from each donor in response to each pathogen as indicated. Each bar represents a distinct sequence, the relative frequency of which is depicted on the y axis. TRBJ gene usage is shown on the x axis labeled for dominant sequences. (B) Distribution of CDR3β amino acid lengths from all TRBV gene–defined MAIT cells responsive to each pathogen as indicated in the key. (C) Visual representation of amino acid enrichments at each position across the CDR3β core compiled from pathogen-reactive MAIT cell TRBV+ sequences. Analysis was confined to CDR3β sequences with a length of 13 or 14 amino acids, encompassing 34 sequences for M. smegmatis, 75 for S. typhimurium, and 39 for C. albicans. Graphics were generated using Seq2Logo.

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