Mice receiving bone marrow from Nlrp3^−/− animals develop enhanced gastrointestinal disease. (A) Schematic of the four stage model of inflammation-driven tumor progression using the chemical carcinogen AOM in bone marrow chimeric mice. (B) Weight change of indicated BM chimeras. (C) Composite clinical scores reflecting weight loss, loose stool consistency, and blood in the stool and rectum. (D) Colon length. (E) Composite HAI scores. (F) Quantification of macroscopic polyps. Data depict the mean ± SEM and are representative of three independent experiments. The symbol * indicates P < 0.05 in a comparison of the WT→WT control to the other three groups. WT→Nlrp3^−/−, n = 7; Nlrp3^−/−→WT, n = 7; WT→WT, n = 3; Nlrp3^−/−→Nlrp3^−/−, n = 3.