Loss of Nlrp3 results in augmented features of ulcerative colitis in the inflammation-driven tumor model. (A) Schematic of the CAC model using the chemical carcinogen AOM and DSS. (B and C) Weight loss measured throughout the colitis driven tumor progression model in WT, Nlrp3^−/−, and Nlrc4^−/− mice (difference observed during the final week of study in C is not statistically significant). (D) Clinical scores reflecting weight loss, loose stool consistency, and amounts of blood present in stool and rectum. (E) Colon length. (F) Gross morphology revealing areas of excessive wall thickening and hemorrhage. Data shown are representative of 3 independent experiments and depict the mean ± SEM. Error bars have been omitted from the weight loss data for clarity of presentation. The symbols # and § indicate P < 0.05 and P < 0.01, respectively, between the AOM/mock and AOM/DSS-treated WT; * indicates P < 0.05 between the Nlrp3^−/− and WT mice. WT, n = 15; Nlrp3^−/−, n = 12; Nlrc4^−/−, n = 4; WT AOM/mock, n = 3.