Nogo-A/B KO mice display exaggerated antigen-driven Th2 inflammatory responses. (A) Representative lung sections from allergic WT and Nogo-A/B KO (KO). (B) Total and differential cell counts in BAL fluid from WT and KO control and OVA-challenged mice (*, P < 0.01). (C) Levels of Th2 cytokines IL-13, IL-4, and IL-5 and IFN-γ as a Th1 cytokine for control were measured in BAL of WT and KO OVA mice (*, P < 0.05). (D) Levels of OVA-specific IgE in serum of WT and KO control mice and in OVA mice before (sensitized only) and after challenge (*, P = 0.013). (E) Total cells and eosinophils were measured in BAL of allergic WT and KO mice as described in Results. *, statistically significant from WT mice. (F) 7 and 14 d after 3-d challenge (*, P < 0.05). (G and H) Lung histology (G) and cell counts (H) in BAL in OVA-challenged BMT mice (*, P < 0.05). Data are expressed as the mean ± SEM. n = 4–8 mice for all groups representative of four individual experiments. Bars, 100 µm.