Figure 4.
Figure 4. Comparison of the interactions between citrulline and arginine in the P4 pocket of HLA-DRB1*04:02. (a) Vimentin-71Cit66-78 colored in green; (b) Vimentin66-78 colored in purple. The solvent-accessible electrostatic potential was calculated for panel c HLA-DRB1*04:01 and (d) HLA-DRB1*04:02 bound to vimentin-71Cit66-78. Electrostatic calculations were performed using APBS (±12 kT/e).

Comparison of the interactions between citrulline and arginine in the P4 pocket of HLA-DRB1*04:02. (a) Vimentin-71Cit66-78 colored in green; (b) Vimentin66-78 colored in purple. The solvent-accessible electrostatic potential was calculated for panel c HLA-DRB1*04:01 and (d) HLA-DRB1*04:02 bound to vimentin-71Cit66-78. Electrostatic calculations were performed using APBS (±12 kT/e).

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