ST2 is necessary for host immunity against N. brasiliensis. (A) N. brasiliensis fecal egg numbers in WT C57BL/6 mice after treatment with anti-T1/ST2 mAb or isotype control on days 0 and 4. Means ± SE of six mice/group are shown. (B) N. brasiliensis intestinal worm numbers at day 9 after infection from the experiment described in A. Means ± SE of six mice/group are shown. Data are representative of two independent experiments (*, P < 0.05; **, P < 0.01; and ***, P < 0.001).