Figure 2.
Figure 2. TFF2 is required for IL-13–driven allergic airway inflammation and airway hyperresponsiveness. (A) Airway pressure time index (APTI) of WT and TFF2−/− mice was measured 8 d after administration of rIL-13 (5 µg/mouse) or vehicle (1× PBS). Data represent mean ± SE of eight mice/group. (B) Quantification of PAS-positive cells within airway epithelium at day 8 after injection of rIL-13 or PBS. Data represent mean ± SE of eight mice/group. (C) Numbers of epithelia, macrophages, eosinophils, and lymphocytes in BAL fluid at day 8 after injection of rIL-13 or PBS. Data represent mean ± SE of eight mice/group. (D) Quantification of mRNA transcripts encoding RETNLB, MUC5AC, CLCA3, and RETNLA in the lung at day 8 after injection of rIL-13 or PBS. Data represent mean ± SE of four to six mice/group. Data are representative of four independent experiments (***, P < 0.001).

TFF2 is required for IL-13–driven allergic airway inflammation and airway hyperresponsiveness. (A) Airway pressure time index (APTI) of WT and TFF2−/− mice was measured 8 d after administration of rIL-13 (5 µg/mouse) or vehicle (1× PBS). Data represent mean ± SE of eight mice/group. (B) Quantification of PAS-positive cells within airway epithelium at day 8 after injection of rIL-13 or PBS. Data represent mean ± SE of eight mice/group. (C) Numbers of epithelia, macrophages, eosinophils, and lymphocytes in BAL fluid at day 8 after injection of rIL-13 or PBS. Data represent mean ± SE of eight mice/group. (D) Quantification of mRNA transcripts encoding RETNLB, MUC5AC, CLCA3, and RETNLA in the lung at day 8 after injection of rIL-13 or PBS. Data represent mean ± SE of four to six mice/group. Data are representative of four independent experiments (***, P < 0.001).

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