Figure 1. Rnaseh2c−/− mice die in utero around day E9.5. (A) Targeting strategy for the generation of Rnaseh2c−/− mice. Probe, position of the probe for Southern blot analysis. A, ApaLI cleavage site; HR, homologous recombination; DT, diphtheria toxin; NEO, neomycin/G418 resistance cassette. (B) Southern blot of a targeted ES cell clone. (C) Weaned offspring from heterozygous (Rnaseh2c−/WT) breedings. (D) Embryos from heterozygous (Rnaseh2c−/WT) breedings at E9.5.
Figure 1.

Rnaseh2c−/− mice die in utero around day E9.5. (A) Targeting strategy for the generation of Rnaseh2c−/− mice. Probe, position of the probe for Southern blot analysis. A, ApaLI cleavage site; HR, homologous recombination; DT, diphtheria toxin; NEO, neomycin/G418 resistance cassette. (B) Southern blot of a targeted ES cell clone. (C) Weaned offspring from heterozygous (Rnaseh2c−/WT) breedings. (D) Embryos from heterozygous (Rnaseh2c−/WT) breedings at E9.5.

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