Figure 2. CSB deficiency increases whole body metabolism. (A) 1 wk food intake CSBm/m compared with age-matched WT mice (n = 3; data are represented as mean ± SEM). (B and C) HE staining of the small (B) and large (C) intestines (n = 3). (D) Mice were placed in metabolic cages for 72 h. O2 consumption and CO2 production were measured. D1= dark phase 1, L1 = light phase 1, etc. (n = 3–8; data are represented as mean ± SEM; *, P < 0.05; **, P < 0.01; ***, P < 0.001). (E) Gene ontology terms of a microarray comparing MDFs from WT and CSBm/m mice (n = 3–4; blue is down-regulated and red is up-regulated).
Figure 2.

CSB deficiency increases whole body metabolism. (A) 1 wk food intake CSBm/m compared with age-matched WT mice (n = 3; data are represented as mean ± SEM). (B and C) HE staining of the small (B) and large (C) intestines (n = 3). (D) Mice were placed in metabolic cages for 72 h. O2 consumption and CO2 production were measured. D1= dark phase 1, L1 = light phase 1, etc. (n = 3–8; data are represented as mean ± SEM; *, P < 0.05; **, P < 0.01; ***, P < 0.001). (E) Gene ontology terms of a microarray comparing MDFs from WT and CSBm/m mice (n = 3–4; blue is down-regulated and red is up-regulated).

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