Figure 1. The old CSBm/m mice show signs of neurodegeneration and universal loss of fat. (A) Quantification of adipose tissue using T1-weighted MRI in young (2 mo) and old (20 mo) WT and CSBm/m mice (n = 3; data are represented as mean ± SEM). (B) Representative axial T1-weighted MRI scans of the CSBm/m and WT mice. Yellow denotes fat. (C) Respiration rates of mice during the MRI scans. (D) HE staining of abdominal skin in young and old WT and CSBm/m mice. The bar denotes the subcutaneous fat layer (n = 3). (E) HE staining of the liver. (F) Periodic acid-Schiff staining of the liver of the 20-mo-old mice with and without diastase to show glycogen content. (G) HE staining of the inner ear. The star denotes the spiral ganglion (n = 3). (H) Brain weight of WT and CSBm/m mice (n = 3; data are represented as mean ± SEM).
Figure 1.

The old CSBm/m mice show signs of neurodegeneration and universal loss of fat. (A) Quantification of adipose tissue using T1-weighted MRI in young (2 mo) and old (20 mo) WT and CSBm/m mice (n = 3; data are represented as mean ± SEM). (B) Representative axial T1-weighted MRI scans of the CSBm/m and WT mice. Yellow denotes fat. (C) Respiration rates of mice during the MRI scans. (D) HE staining of abdominal skin in young and old WT and CSBm/m mice. The bar denotes the subcutaneous fat layer (n = 3). (E) HE staining of the liver. (F) Periodic acid-Schiff staining of the liver of the 20-mo-old mice with and without diastase to show glycogen content. (G) HE staining of the inner ear. The star denotes the spiral ganglion (n = 3). (H) Brain weight of WT and CSBm/m mice (n = 3; data are represented as mean ± SEM).

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