Genista NK cells regain full reactivity in a WT environment. Purified Genista spleen NK cells were transferred to WT or Genista (G) hosts, as indicated. 7 d after transfer, the frequency of IFN-γ–producing cells among transferred Genista NK cells (shaded bars) was analyzed after stimulation with isotype control, anti-NK1.1, and anti-NKp46 mAb-coated plates or a mix of PMA and ionomycin. The reactivity of NK cells from WT or Genista hosts was indicated as controls (open bars). Experiments were repeated three times. n = 2–3. Statistical significance was determined with a Mann-Whitney test. *, P < 0.05; **, P < 0.01; ***, P < 0.001.