Figure 5.
Figure 5. ApoE−/−/TRAIL−/− mice are protected from the development of PAH. (A–D) Bar graphs show RVSP (A), RVEDP (B), LVESP (C), and LVEDP (D), measured in mm Hg. (E–H) PA AT (E), cardiac index (F), ePVRi (G), and RVH (H) are shown. (I) The degree of medial wall thickness as a ratio of total vessel size (Media/CSA) in pulmonary arteries <50 µm in diameter. (J) Representative photomicrographs of serial lung sections from TRAIL−/−, ApoE−/−, and ApoE−/−/TRAIL−/− mice fed on either regular chow or Paigen diet for 8 wk. Sections were stained with Alcian Blue Elastic van Gieson (ABEVG) or immunostained for α-SMA or von Willebrand factor (vWF). Error bars represent mean ± SEM, n = 4–7 animals per group. *, P < 0.05; **, P < 0.01; ***, P < 0.001, compared with chow-fed mice. Bars, 50 µm.

ApoE−/−/TRAIL−/− mice are protected from the development of PAH. (A–D) Bar graphs show RVSP (A), RVEDP (B), LVESP (C), and LVEDP (D), measured in mm Hg. (E–H) PA AT (E), cardiac index (F), ePVRi (G), and RVH (H) are shown. (I) The degree of medial wall thickness as a ratio of total vessel size (Media/CSA) in pulmonary arteries <50 µm in diameter. (J) Representative photomicrographs of serial lung sections from TRAIL−/−, ApoE−/−, and ApoE−/−/TRAIL−/− mice fed on either regular chow or Paigen diet for 8 wk. Sections were stained with Alcian Blue Elastic van Gieson (ABEVG) or immunostained for α-SMA or von Willebrand factor (vWF). Error bars represent mean ± SEM, n = 4–7 animals per group. *, P < 0.05; **, P < 0.01; ***, P < 0.001, compared with chow-fed mice. Bars, 50 µm.

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