Figure 2. Increased TNF-induced osteoclastogenesis and bone resorption in vivo in mice with myeloid-specific RBP-J deficiency. (A) μCT analysis of the femurs of 8-wk-old male Rbpj+/+ or RbpjΔM/ΔM littermates was performed. BV/TV, trabecular bone volume/tissue volume; Tb.N, trabecular number; Tb.Th, trabecular bone thickness; Tb.Sp, trabecular separation. n = 5 in each group. NS, no statistically significant difference. (B) TRAP staining of histological sections and (C) the concentration of serum TRAP obtained from Rbpj+/+ and RbpjΔM/ΔM littermates (8-wk-old) with or without TNF administration (75 µg/kg body weight). Bar, 200 µm in B. n = 5 per group. **, P < 0.01. Data are representative of two independent experiments (A–C).
Figure 2.

Increased TNF-induced osteoclastogenesis and bone resorption in vivo in mice with myeloid-specific RBP-J deficiency. (A) μCT analysis of the femurs of 8-wk-old male Rbpj+/+ or RbpjΔM/ΔM littermates was performed. BV/TV, trabecular bone volume/tissue volume; Tb.N, trabecular number; Tb.Th, trabecular bone thickness; Tb.Sp, trabecular separation. n = 5 in each group. NS, no statistically significant difference. (B) TRAP staining of histological sections and (C) the concentration of serum TRAP obtained from Rbpj+/+ and RbpjΔM/ΔM littermates (8-wk-old) with or without TNF administration (75 µg/kg body weight). Bar, 200 µm in B. n = 5 per group. **, P < 0.01. Data are representative of two independent experiments (A–C).

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