Loss of B7x results in exacerbated disease after adoptive transfer of diabetogenic T cells. (A–C) After transfer of activated BDC2.5 cells into sublethally irradiated recipient mice, urine glucose levels were measured every 2 d. Mice were considered diabetic after two consecutive measurements exceeded 250 mg/dl. B7x-deficient mice (blue) exhibited a more severe disease in comparison with wild-type mice (black) when we examined disease incidence (A), mean glucose measurements (B), and survival (C; n = 15 mice per group). Data were pooled from three independent experiments.