Figure 7. Expression of proNGF receptors during cardiac vessel development. E18.5 (A, B, and E) or E20.5 (C and D) C57BL6/J embryos were analyzed for p75NTR and SorCS2 immunoreactivity (hearts from Ngf+/+ and proNgf-HA/+ embryos yielded similar results). (A and B) p75NTR (green) does not colocalize with IB4 (red) on endothelial cells (A) but does colocalize with PDGFR-β (red), which labels pericytes (B). (C and D) SorCS2 immunoreactivity (green) is detected on a subset of PDGFR-β–immunopositive pericytes (red) at E20.5 but not on IB4+ endothelial cells (red). (E) p75NTR and SorCS2 are colocalized on some pericytes at E18.5. Single channel and overlays are shown. Bar, 25 µm. n = 3 mice per age.
Figure 7.

Expression of proNGF receptors during cardiac vessel development. E18.5 (A, B, and E) or E20.5 (C and D) C57BL6/J embryos were analyzed for p75NTR and SorCS2 immunoreactivity (hearts from Ngf+/+ and proNgf-HA/+ embryos yielded similar results). (A and B) p75NTR (green) does not colocalize with IB4 (red) on endothelial cells (A) but does colocalize with PDGFR-β (red), which labels pericytes (B). (C and D) SorCS2 immunoreactivity (green) is detected on a subset of PDGFR-β–immunopositive pericytes (red) at E20.5 but not on IB4+ endothelial cells (red). (E) p75NTR and SorCS2 are colocalized on some pericytes at E18.5. Single channel and overlays are shown. Bar, 25 µm. n = 3 mice per age.

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