Figure 6. Abnormalities in the microvasculature of hearts from proNgf-HA/+ mice. (A–C) Hearts from proNgf-HA/+ mice at postnatal day 9 analyzed for platelet deposition (as assessed by CD41 immunofluorescence, red) compared with Ngf+/+ and with p75−/−; proNgf-HA/+ myocardium. (D–F) ICAM-1 expression (red) in the proNgf-HA/+ myocardium compared with the Ngf+/+ and p75−/−;proNgf-HA/+ myocardium, at postnatal day 9. (G–I) FITC-dextran (green) accumulation and extravasation was examined in the myocardium from 3-mo-old proNgf-HA/+, Ngf+/+ and p75−/−;proNgf-HA/+ mice. (J and K) Quantification of CD41 and ICAM-1 immunofluorescence (n = 3–6 mice/condition, eight fields of view per mouse). *, P < 0.05; **, P < 0.01, mean ± SEM. Bar, 100 µm.
Figure 6.

Abnormalities in the microvasculature of hearts from proNgf-HA/+ mice. (A–C) Hearts from proNgf-HA/+ mice at postnatal day 9 analyzed for platelet deposition (as assessed by CD41 immunofluorescence, red) compared with Ngf+/+ and with p75−/−; proNgf-HA/+ myocardium. (D–F) ICAM-1 expression (red) in the proNgf-HA/+ myocardium compared with the Ngf+/+ and p75−/−;proNgf-HA/+ myocardium, at postnatal day 9. (G–I) FITC-dextran (green) accumulation and extravasation was examined in the myocardium from 3-mo-old proNgf-HA/+, Ngf+/+ and p75−/−;proNgf-HA/+ mice. (J and K) Quantification of CD41 and ICAM-1 immunofluorescence (n = 3–6 mice/condition, eight fields of view per mouse). *, P < 0.05; **, P < 0.01, mean ± SEM. Bar, 100 µm.

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