HP-β-CD treatment prominently reduces the levels of Aβ in brain extracts from Tg19959 mice. (A) Representative image of Western blots of Aβ, detected with 6E10 antibody and normalized to tubulin. *, P < 0.05. (B) Levels of Aβ42 and Aβ40 examined by ELISA. *, P < 0.05. (C) Western blots of β-CTFs (left gel) using 6E10 antibody. Short exposure image shows full-length APP. The levels of β-CTFs were normalized to tubulin. (D) The same membrane stripped and re-blotted with an APP C-terminal antibody to show α- and β-CTFs. n = 4 (Tg); n = 7 (Tg-CD). All results were analyzed from two separate animal studies.