Figure 3. CL1-R2 inhibits FGF2-induced neoangiogenesis in a Matrigel plug model. (A, Top) Photographs of representative FGF2-containing Matrigel plugs taken from control IgG1- and CL1-R2–treated mice 7 d after plug implantation. (A, Bottom) Representative sections of FGF2-containing Matrigel plugs taken from control IgG1- and CL1-R2–treated mice on day 7. Endothelial cells were labeled with isolectin B4 (brown) and the sections were counterstained with hematoxylin (blue). Arrowheads indicate isolectin B4-positive vessels. Bar, 50 µm. Representative images of five independent experiments. (B) Quantification of hemoglobin in FGF2-containing Matrigel plugs removed from control IgG1- and CL1-R2–treated mice. Horizontal bars represent the mean hemoglobin content. n = 11 IgG1-treated mice; n = 22 CL1-R2–treated mice. *, P = 0.0153 (Mann-Whitney U test). Pooled data are from five independent experiments.
Figure 3.

CL1-R2 inhibits FGF2-induced neoangiogenesis in a Matrigel plug model. (A, Top) Photographs of representative FGF2-containing Matrigel plugs taken from control IgG1- and CL1-R2–treated mice 7 d after plug implantation. (A, Bottom) Representative sections of FGF2-containing Matrigel plugs taken from control IgG1- and CL1-R2–treated mice on day 7. Endothelial cells were labeled with isolectin B4 (brown) and the sections were counterstained with hematoxylin (blue). Arrowheads indicate isolectin B4-positive vessels. Bar, 50 µm. Representative images of five independent experiments. (B) Quantification of hemoglobin in FGF2-containing Matrigel plugs removed from control IgG1- and CL1-R2–treated mice. Horizontal bars represent the mean hemoglobin content. n = 11 IgG1-treated mice; n = 22 CL1-R2–treated mice. *, P = 0.0153 (Mann-Whitney U test). Pooled data are from five independent experiments.

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