Figure 2.
Figure 2. TSP-1 regulates the lymphangiogenic response in a mouse model of inflammation-associated corneal neovascularization. Representative segments of corneal flat mounts from WT and TSP-1−/− mice stained with CD31 are shown in green (blood vessels) and LYVE-1 is shown in red (lymphatic vessels; A; Li, Limbal vascular arcade: bottom, center of the cornea: top; B; L, lymph vessels). (C) Morphometric quantification of lymphvascularized area in WT and TSP-1−/− mice (*, P < 0.05; n = 10 per group; age 8 wk). (D) Morphometric analysis of vascularized areas with lymphatic vessels in sutured corneas of WT mice treated with three subconjunctival injections and topical eye drops (x3 daily) of recombinant human (rh) TSP-1 in comparison to control (*, P < 0.05; n = 8 per group, age 8 wk). Error bars indicate SD.

TSP-1 regulates the lymphangiogenic response in a mouse model of inflammation-associated corneal neovascularization. Representative segments of corneal flat mounts from WT and TSP-1−/− mice stained with CD31 are shown in green (blood vessels) and LYVE-1 is shown in red (lymphatic vessels; A; Li, Limbal vascular arcade: bottom, center of the cornea: top; B; L, lymph vessels). (C) Morphometric quantification of lymphvascularized area in WT and TSP-1−/− mice (*, P < 0.05; n = 10 per group; age 8 wk). (D) Morphometric analysis of vascularized areas with lymphatic vessels in sutured corneas of WT mice treated with three subconjunctival injections and topical eye drops (x3 daily) of recombinant human (rh) TSP-1 in comparison to control (*, P < 0.05; n = 8 per group, age 8 wk). Error bars indicate SD.

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