Figure 6. miR-204 level decreases within distal PAs of rats injected with MCT during the fourth week of PAH development. (A) miR-204 expression relative to U6 measured by qRT-PCR in distal PAs of rats. (B) SHP2 protein expression was quantified in distal PAs by immunofluorescence (F.U., fluorescent unit) on lung sections (n = 5 measurements by rat in five rats per time point). (C and D) STAT3 and NFAT activation were measured by the percentage of cells presenting p-STAT3 and NFAT nuclear localization, respectively, in distal PAs of rats (n = 5 measurements by rat in 10 rats per time point). (E) Mean PA pressure measured by right catheterization in closed chest rats (n = 5 rats per group). Graphs represent means ± SEM (*, P < 0.05; **, P < 0.01; ***, P < 0.001).
Figure 6.

miR-204 level decreases within distal PAs of rats injected with MCT during the fourth week of PAH development. (A) miR-204 expression relative to U6 measured by qRT-PCR in distal PAs of rats. (B) SHP2 protein expression was quantified in distal PAs by immunofluorescence (F.U., fluorescent unit) on lung sections (n = 5 measurements by rat in five rats per time point). (C and D) STAT3 and NFAT activation were measured by the percentage of cells presenting p-STAT3 and NFAT nuclear localization, respectively, in distal PAs of rats (n = 5 measurements by rat in 10 rats per time point). (E) Mean PA pressure measured by right catheterization in closed chest rats (n = 5 rats per group). Graphs represent means ± SEM (*, P < 0.05; **, P < 0.01; ***, P < 0.001).

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