Figure 2. Inflammation of the footpad accelerates DDC movement in the dermis. (a and b) Extended focus snapshots of the dermis in the steady-state (a) or 24 h after injecting CFA s.c. (b). Tracks show the motion of selected DDCs through 45 min (arrowheads indicate the endpoints of tracked cells). (c and d) Charts representing the three-dimensional paths, normalized to their starting coordinates, taken by the cells tracked above. (e and f) Crawling velocities (e) and arrest coefficients (f). Shown is the percentage of time in which cells were immobile (slower than 2 µm/min). Data points represent individual cells (n of steady state = 535, n of CFA-treated = 305) and were pooled from six mice and 15 movies for each condition. Red bars denote the mean. Inflammation increased velocities and reduced arrest. *, P < 0.0001 for both.
Figure 2.

Inflammation of the footpad accelerates DDC movement in the dermis. (a and b) Extended focus snapshots of the dermis in the steady-state (a) or 24 h after injecting CFA s.c. (b). Tracks show the motion of selected DDCs through 45 min (arrowheads indicate the endpoints of tracked cells). (c and d) Charts representing the three-dimensional paths, normalized to their starting coordinates, taken by the cells tracked above. (e and f) Crawling velocities (e) and arrest coefficients (f). Shown is the percentage of time in which cells were immobile (slower than 2 µm/min). Data points represent individual cells (n of steady state = 535, n of CFA-treated = 305) and were pooled from six mice and 15 movies for each condition. Red bars denote the mean. Inflammation increased velocities and reduced arrest. *, P < 0.0001 for both.

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