Figure 3. Electrophysiology study of the CaMKII-TDP-43 Tg mice. (A) Attenuated LTP in the hippocampus of 2-mo-old CaMKII-TDP-43 Tg mice. LTP was induced by strong tetanus stimulation in the stratum radiatum layer of CA1. Results represent the mean ± SEM of three independent experiments (n = 18 mice/group). (B) Recording of altered mEPSCs in the primary hippocampal culture of CaMKII-TDP-43 Tg mice. Whole-cell voltage clamp recordings of cultured hippocampal neurons (12–15 DIV) from the WT and TDP-43 Tg mice were performed. Representative traces of the mEPSCs recorded from the neurons are shown on top. The frequencies, amplitudes, decay τ, and rise τ of the mEPSCs are shown in the histograms. *, P < 0.05; ***, P < 0.001. The scale bars are 50 pA and 1 s, respectively. Results represent the mean ± SEM of three independent (n = 10 mice/group).
Figure 3.

Electrophysiology study of the CaMKII-TDP-43 Tg mice. (A) Attenuated LTP in the hippocampus of 2-mo-old CaMKII-TDP-43 Tg mice. LTP was induced by strong tetanus stimulation in the stratum radiatum layer of CA1. Results represent the mean ± SEM of three independent experiments (n = 18 mice/group). (B) Recording of altered mEPSCs in the primary hippocampal culture of CaMKII-TDP-43 Tg mice. Whole-cell voltage clamp recordings of cultured hippocampal neurons (12–15 DIV) from the WT and TDP-43 Tg mice were performed. Representative traces of the mEPSCs recorded from the neurons are shown on top. The frequencies, amplitudes, decay τ, and rise τ of the mEPSCs are shown in the histograms. *, P < 0.05; ***, P < 0.001. The scale bars are 50 pA and 1 s, respectively. Results represent the mean ± SEM of three independent (n = 10 mice/group).

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