Figure 3. Frequencies and phenotype of NK cells in MOG-immunized mice treated with IL-2 complexes. Upon EAE induction with MOG, B6 mice were treated with control IgG, IL-2, anti–IL-2 mAb (S4B6), or a combination of IL-2 and anti–IL-2 mAb (IL-2 C) i.p. as indicated in Materials and methods. Single cell suspensions were prepared from the spleen and CNS of mice on days 12–20, and the frequencies and phenotypes of mononuclear cells were analyzed by FACS. (A) The frequencies of NK and NKT cells in the periphery and CNS. (B) Expression of NKG2A on NK cells. (C) Production of IFN-γ by NK cells. P-values were determined by a Student’s t test. The dot plots are representative of three separate experiments (n = 5–15/group). Error bars represent the means ± SEM.
Figure 3.

Frequencies and phenotype of NK cells in MOG-immunized mice treated with IL-2 complexes. Upon EAE induction with MOG, B6 mice were treated with control IgG, IL-2, anti–IL-2 mAb (S4B6), or a combination of IL-2 and anti–IL-2 mAb (IL-2 C) i.p. as indicated in Materials and methods. Single cell suspensions were prepared from the spleen and CNS of mice on days 12–20, and the frequencies and phenotypes of mononuclear cells were analyzed by FACS. (A) The frequencies of NK and NKT cells in the periphery and CNS. (B) Expression of NKG2A on NK cells. (C) Production of IFN-γ by NK cells. P-values were determined by a Student’s t test. The dot plots are representative of three separate experiments (n = 5–15/group). Error bars represent the means ± SEM.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal