Human DLBCL patients exhibit reduced PTEN and SHIP expression compared with FL patients. (A) cDNA expression analysis of human malignant B cell lymphoma samples from publicly available patient data (www.oncomine.org) comparing normal B cells, FL, and DLBCL showing mean (black lines) relative expression values for PTEN and SHIP cDNA. Each square represents an expression value for a single patient/sample. P-values comparing normal cells and DLBCL cells are indicated. (B) Mean Log₂ normalized expression of PTEN and SHIP is plotted for the following patient groups: PTEN low (lowest 25% PTEN expression), SHIP low (lowest 25% SHIP expression), and BCL6 high (highest 25% BCL6 expression), in comparison with mean values for all patients which were near 0. Analyses of other genes in the PTEN and SHIP low patient cohort confirmed that results were not a result of generally low cDNA signals in this cohort. *, P < 0.05; **, P < 0.005.