Figure 9.
Figure 9. Summary of the fraction of block by MOPS− at −80 mV for the data presented in Fig. 8. The O1 state is more sensitive to MOPS− than the O2 state for mutants with the net charge in the internal vestibule unaltered or the positive one added. Using WT channels as a control, it appears that these mutations increase MOPS− block of the O1 state, not of the O2 state. But for mutants with the net charge of minus one (N306D and R303C/Cysless), the O1 and O2 states are equally sensitive to MOPS−. For some data points, the error bars are smaller than the symbol because of small SEM. n = 3–4.

Summary of the fraction of block by MOPS− at −80 mV for the data presented in Fig. 8 . The O1 state is more sensitive to MOPS− than the O2 state for mutants with the net charge in the internal vestibule unaltered or the positive one added. Using WT channels as a control, it appears that these mutations increase MOPS− block of the O1 state, not of the O2 state. But for mutants with the net charge of minus one (N306D and R303C/Cysless), the O1 and O2 states are equally sensitive to MOPS−. For some data points, the error bars are smaller than the symbol because of small SEM. n = 3–4.

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