Figure 1.
Figure 1. CNG channel topology and homologous C-terminal structures. (A) Schematic drawing of CNG channel topology. Two structural elements underlying the response to PIPs, located on the inner leaflet on lipid membrane, have been identified in the N and C terminus of CNG channels, respectively. (B) Left, crystal structure of human HCN4 channel C-terminal fragment (Xu et al., 2010). Right, overlay of HCN and zebrafish ELK C-terminal structures (Brelidze, T.I., F. DiMaio, M.C. Trudeau, and W.N. Zagotta. 2013. Biophysical Society 57th Annual Meeting. Abstr. 1826-plat). The CNBDs can be aligned well but the C-linkers cannot.

CNG channel topology and homologous C-terminal structures. (A) Schematic drawing of CNG channel topology. Two structural elements underlying the response to PIPs, located on the inner leaflet on lipid membrane, have been identified in the N and C terminus of CNG channels, respectively. (B) Left, crystal structure of human HCN4 channel C-terminal fragment (Xu et al., 2010). Right, overlay of HCN and zebrafish ELK C-terminal structures (Brelidze, T.I., F. DiMaio, M.C. Trudeau, and W.N. Zagotta. 2013. Biophysical Society 57th Annual Meeting. Abstr. 1826-plat). The CNBDs can be aligned well but the C-linkers cannot.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal