Figure 3. Concentration dependence of... | Rockefeller University Press

Figure 3.

$Figure 3. Concentration dependence of Tz1 effects on NaV1.4 and NaV1.5 channels. (A) The estimated probabilities of NaV1.4 channels to be inhibited (Pi) or preactivated (Pa) by Tz1 in the absence (gray symbols; −pp) or presence (black symbols; +pp) of a prepulse as a function of the Tz1 concentration. Ptox (open circles) is the sum of Pi and Pa and independent of a prepulse; i.e., Ptox is a measure of the fraction of NaV channels with Tz1 bound. Continuous curves are global data fits according to a Hill equation (Eq. 3). (B) Estimated probabilities for NaV1.5 channels to be inhibited (Pi) by Tz1 versus Tz1 concentration. For data fits in A and B, a Hill coefficient of unity was assumed.$

Concentration dependence of Tz1 effects on Na_V1.4 and Na_V1.5 channels. (A) The estimated probabilities of Na_V1.4 channels to be inhibited (P_i) or preactivated (P_a) by Tz1 in the absence (gray symbols; −pp) or presence (black symbols; +pp) of a prepulse as a function of the Tz1 concentration. P_tox (open circles) is the sum of P_i and P_a and independent of a prepulse; i.e., P_tox is a measure of the fraction of Na_V channels with Tz1 bound. Continuous curves are global data fits according to a Hill equation (Eq. 3). (B) Estimated probabilities for Na_V1.5 channels to be inhibited (P_i) by Tz1 versus Tz1 concentration. For data fits in A and B, a Hill coefficient of unity was assumed.