Acidosis and Ca2+ signaling. Time course of changes in CaTs during extracellular, intracellular, and combined acidosis. Myocytes (rabbit) were field stimulated at CL = 2 s. (A) Representative examples from three cells showing the effects of a 2-min application of the acidifying solutions. Below each panel are the CaTs recorded during control and after 2 min of acidosis (red), indicated by arrows. (B) Summarized CaT parameters for extracellular (n = 7), intracellular (n = 12), and combined acidosis (n = 6). Results are expressed as percent change relative to control immediately before applying the acidifying solutions. (a) CaT systolic, systolic value of the CaT; (b) CaT diastolic, diastolic value of the CaT; (c) CaT amplitude, amplitude of the CaT; (d) CaT derivative, rate of rise of the CaT (arbitrary units); (e) CaT duration90, duration of the CaT at 90% recovery. **, P < 0.01; *, P < 0.05, paired; control compared with 2 min of acidosis.
