Sequence comparisons among different species and other KCNQ channels. KCNQ1 amino acid sequences of part of the S1 segment (122–135), S5 segment (269–275), S5-P connector (286–298), and the upper half of the S6 segment (324–334) from various species are aligned. Other types of KCNQ channels (KCNQ2-5) from humans are also aligned. Conserved Phe123, Phe127, Phe130, Gly272, Val324, and Val334 are colored in red. Conserved amino acid residues are highlighted in bold.